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| What is the Optimal Form
of Testosterone for Replacement Therapy? |
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| Testosterone USP is natural bio-identical
testosterone that has been approved by the United
States Pharmacopoeia and is available as a bulk
chemical. Upon a prescription order, compounding
pharmacists can use Testosterone USP to prepare
numerous dosage forms. |
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| Natural Testosterone Replacement
is Central to the Treatment of All Facets of Andropause.
The term "testosterone" is often used
generically when referring to numerous synthetic
derivatives, as well as natural bio-identical testosterone.
Confusion is responsible for conflicting data in
the medical literature about the benefits and risks
of testosterone therapy. Studies must be reviewed
carefully to determine the form of testosterone
that was used. Natural testosterone must not be
confused with synthetic derivatives or "anabolic
steroids," which when used by athletes and
body builders have caused disastrous effects. For
example, administration of synthetic non-aromatizable
androgens, like stanozolol or methyltestosterone,
causes profound decreases in HDL-C ("good cholesterol")
and significant increases in LDL-C ("bad cholesterol").
Yet, hormone replacement with aromatizable androgens,
such as testosterone, results in lower total cholesterol
and LDL cholesterol levels while having little to
no impact on serum HDL cholesterol levels. Proper
monitoring of laboratory values and clinical response
are essential when prescribing testosterone replacement
therapy. |
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| The only absolute contraindications
to androgen replacement therapy are the presence
of prostate or breast cancer. "Although it
is known that the clinical course of prostate cancer
is accelerated by testosterone, its incidence is
not increased by [testosterone] administration...
There is even no clear evidence that testosterone
replacement accelerates the development of BPH."
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| Drugs & Aging 1999
Aug;15(2):131-42 |
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These statements have not been evaluated
by the Food and Drug Administration. These preparations
are not intended to diagnose, treat, cure, or prevent
any disease. |
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Sandusky: 419-627-2800
• 800-259-6662 | Perrysburg: 419-873-2800
• 800-318-3408
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